Low hematocrit and hemoglobin and high white cell count

Thyroid hormones often have important effect on erythropoiesis.

Thyroid disorders are frequently accompanied by red blood cell abnormalities. The most common disorders of the thyroid gland include hyperthyroidism, hypothyroidism and thyroid nodules, which are generally benign thyroid neoplasm but may change to thyroid cancer. Other effects of thyroid hormones include involvement in hemoglobin production in adult and maturation of Hb in fetus ( 2- 4). The secretion of thyrotropin itself is mediated by thyrotropin-releasing hormone (TRH) secreted by the hypothalamus. Hormonal output from the thyroid is mediated by thyroid stimulating hormone (also known as TSH or thyrotropin) secreted by anterior pituitary. All these functions are regulated by attachment of the active form of thyroid hormone T3 to specific members of the nuclear receptors family (TRa and TR B). These molecules have also critical roles in early brain development, somatic growth, bone maturation, protein synthesis and regulating production of red blood cells.

These hormones are necessary for mediate metabolism rate (how quickly the body uses and stores energy). Thyroid gland synthesizes and secrets two major hormones, known as 3, 5, 3вЂ™-triiodothyronine (T3) and thyroxin, which can sometimes be referred to as 3, 5, 3вЂ™, 5вЂ™-tetraiodothyronine (T4). These follicles store thyroid hormones in the form of Thyroglobulin molecules until body requires them. It has two lobes and is composed of many thin follicular cells with a type of epithelial tissue origin. The thyroid gland, which is the largest and important endocrine gland in human body, is located on the anterior side of the neck, right below the larynx.

Low hematocrit and hemoglobin and high white cell count